I would imagine there'll be significant compatibility problems, I mean I have trouble getting WHDLoad games to run on an 060, I can only imagine that the Coldfire (isn't it the MCF5475 being used?) will be even worse.
I'm not too knowledgeable but I understand that the problem is that with each generation of the chip, old instructions are removed, so the 060 has some instructions missing that old games and software for the Amiga might try and access, the Coldfire, being mainly intended for embedded apps, will have an even more drastically cut down instruction set, meaning (if I have been reading this stuff correctly) even less compatability with certain apps.
TBH I'm not too interested in the Coldfire board for 2 reasons: 1. it HAS to use the Dragon PCI busboard meaning it needs a towered system and 2. we should be trying to change over completely to PPC only, like the Powervixxen boards (which would/should fit in the 1200 desktop) another vapourware product at the moment but then everything is with Amiga these days.